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Projects

Operational research and programme support projects undertaken at NDTBC.

Projects Undertaken At NDTBC

NDTBC conducts a range of operational, clinical and laboratory research projects in collaboration with the Indian Council of Medical Research (ICMR), the Central TB Division and international partners.

List of latest projects undertaken by NDTB Centre

  1. STREAM (The evaluation of a standard treatment regimen of anti-tuberculosis drugs for patients with MDR-TB)
  2. Evaluation of the Efficacy and Safety of a Combination regimen of Bedaquiline, Delamanid, Linezolid and Clofazimine in Adults with Preextensive (Pre-XDR) and Extensively Drug-resistant Pulmonary Tuberculosis (XDR-TB): Prospective Cohort Study
  3. National TB Prevalence Survey in India.
  4. Prevalence, risk factors and laboratory diagnosis of non tuberculosis mycobacterial (NTM) disease; a multicenter study.
  5. Multicentric validation of phage lysin in comparison with MGIT PANTA to control normal flora in processed sputum specimens for rapid detection of Mycobacterium tuberculosis using BACTEC MGIT 960 system.
  6. Short intensified treatment for children with tuberculosis meningitis (SURE) .
  7. Assessment of effectiveness of the 4-month Moxifloxacin containing daily regimen in the treatment of microbiologically confirmed new pulmonary tuberculosis patients.
  8. Redefining TB Diagnosis at Tuberculosis Diagnostic Centres in Delhi through Introduction and Scale-Up of Quality Management Systems (QMS).
  9. Effect of Counselling Intervention on Outcome Among MDR – TB Patients in Delhi.
  10. Mapping of Anti-Mycobacterial drug resistant hotspots under National Tuberculosis Elimination Programme (NTEP) in Delhi State.
  11. Framework for TB care in Prisons in New Delh.
  12. Active Case Findings Campaign of Tuberculosis with people who use intravenous drugs in New Delhi, India.
  13. Active case finding in Night Shelters under SPYM.
  14. Active case finding among inmates of slum areas in Delhi with help of mobile van.
  15. TB prevalence and interventions for reducing TB and LTBI in high risk key population of rickshaw drivers and construction workers.
  16. Improving TB diagnosis at designated microscopy centres by introduction of Quality Management System and optimum utilisation of rapid molecular diagnostics and its cot implications.

List of projects undertaken during last 10 years by NDTB Centre

  1. A pilot study using an electronic TB case management system (TBTMS)
  2. A new paradigm of partnership in TB control through involvement of pharmacists
  3. Assessment of reasons for initial default under the Revised National Tuberculosis Control Programme (RNTCP) in Delhi
  4. Validation of a sample test based on formation of cords for diagnosis of Mycobacterium tuberculosis
  5. Effectiveness of LED-based fluorescence microscopy for detection of tuberculosis
  6. Repeat zonal-level tuberculin survey for estimating annual risk of tuberculosis infection in the North Zone
  7. Rapid screening of ofloxacin resistance among MDR-TB suspects using molecular and solid culture methods
  8. Assessment of barriers to utilization of RNTCP services in an urban slum in Delhi – a community-based study
  9. Accelerating access to quality TB diagnosis for pediatric cases in four major cities in India
  10. Evaluation of the efficacy and safety of a combination regimen of bedaquiline, delamanid, linezolid, and clofazimine in adults with pre-XDR and XDR pulmonary tuberculosis – a prospective cohort study
  11. STREAM: Evaluation of a standard treatment regimen of anti-tuberculosis drugs for patients with MDR-TB
  12. National TB Prevalence Survey
  13. Effect of counselling intervention on treatment outcomes among MDR-TB patients in Delhi
  14. Mapping of anti-mycobacterial drug-resistant hotspots under RNTCP (NTEP) in Delhi
  15. Framework for TB care in prisons in New Delhi
  16. Active case finding of tuberculosis among people who inject drugs in New Delhi
  17. Study of yield of Mycobacterium tuberculosis using molecular diagnostics in pediatric respiratory specimens
  18. Prevalence, risk factors, and laboratory diagnosis of non-tuberculous mycobacterial (NTM) disease – a multicentre study
  19. Active case finding in night shelters under SPYM
  20. Active TB case finding among female sex workers
  21. Screening of healthcare workers in Delhi under NTEP
  22. Delhi State Warmline TB Expert initiative
  23. Contact tracing of TB cases attending NDTB Centre DOT Centre
  24. Active case finding among slum populations in Delhi using mobile van services
  25. Correlation of radiological assessment with microbiological status among TB cases
  26. Multicentre study on diagnostic accuracy and feasibility of Xpert Ultra for detection of TB and rifampicin resistance in adults with suspected pulmonary TB
  27. Accelerating TB notification from the private health sector in Delhi, India
  28. Evaluation of the impact of SMS interventions on TB treatment adherence under RNTCP
  29. BEAT (Building Evidence for Advanced Treatment Against Tuberculosis) study
  30. TB prevalence and interventions for reducing TB and LTBI among high-risk populations (rickshaw drivers and construction workers)
  31. Improving TB diagnosis at designated microscopy centres through quality management systems (QMS) and optimal use of rapid molecular diagnostics
  32. Non-tuberculous mycobacterial (NTM) disease study
  33. SURE Trial Project

Thesis

  1. Evaluation of TrueNat compared with CBNAAT for detection of tubercular meningitis in children and adolescents
  2. Isoniazid resistance in rifampicin-sensitive pulmonary tuberculosis in children and adolescents
  3. Evaluation of fluorescein diacetate (FDA) vital staining versus culture for monitoring treatment response during the first six months in MDR, pre-XDR, and XDR pulmonary tuberculosis patients on longer regimens under the National Tuberculosis Elimination Programme (NTEP)
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